Invitro and invivo examination for bioceramic degradation

Bone is a composite of collagen fibers that are organized by calcium phosphates nanocrystals. tissue engineering has been continuously developing since the concept “tissue engineering” proposed. Biomaterials used as basic material for fabrication scaffolds play vital role in bone engineering. Calcium and bioactive glasses were first bioceramics specifically developed repair. Biological responses such bonding biodegradation properties these materials very important clinical applications. This paper aims to introduce strategy review difference between in-vivo in-vitro investigation there several differences mechanisms investigations. In this regard, various biological degradation discussed effects additives ions metals on performance behavior reviewed. It was found can enhance affecting their performance. We change composition indefinitely controlled fashion tailor dissolution rate. The presence some mineral origins within phosphate structure affect crystal lattice, therefore accelerate well biodegradability.